Aylin Rodan, M.D. Ph.D.
I am a physician-scientist with an interest in hypertension, electrolyte disorders, and the underlying epithelial ion transport mechanisms in the kidney driving these clinical syndromes. I obtained my bachelor’s degree at Yale University and got started in my scientific career studying the role of endoplasmic reticulum chaperones in protein folding. I then enrolled in the Medical Scientist Training Program at UCSF, where I studied the mechanisms of behavioral changes in Drosophila melanogaster in response to alcohol, examining the effects of protein kinase A signaling in different parts of the brain, as well as the role of insulin signaling. I continued at UCSF for internal medicine residency, then moved to Dallas for nephrology fellowship training at UT Southwestern, where I deepened my understanding of renal physiology and clinical nephrology. The next logical step was to use my favorite organism, Drosophila, to study questions of relevance to mammalian renal physiology. Using this system, my lab is now studying ion channels and transporters, and the signaling cascades that regulate them, in the Drosophila renal tubule; this work is ongoing at the University of Utah. Our goal is to understand these transporters, channels and their regulation in greater mechanistic detail, identify new regulatory factors by performing forward genetic screens, and translate these insights into improved understanding of human kidney disorders. We also have projects studying ion transport pathways in osmoregulation, circadian rhythm and stroke. I also see patients with kidney disorders and teach undergraduate, graduate and medical students and housestaff, with an emphasis on renal physiology.