Rothenfluh Lab Publications

Lathen DR, Merrill CB, Ducker GSRodan AR, Rothenfluh A. (2022)  One-carbon pathways and methylation potential in glutamatergic neurons regulate behavioral alcohol responses. BioRXiv

Philyaw TJTitos I, Cummins PNRodan AR, Rothenfluh A. (2022)  Drosophila Cocaine Avoidance is Mediated by Peripheral Bitter Gustatory Neurons. BioRXiv

Merrill CB,Pabon MA, Montgomery AB, Rodan AR, Rothenfluh A. (2022)  Optimized assay for transposon-accessible chromatin by sequencing (ATAC-seq) preparation from adult Drosophila melanogaster neurons. BioRXiv LINK.  Scientific Reports 12: 6043  LINK

Schellinger JNSun Q, Pleinis JM, An S-W, Hu J, Mercenne G, Titos I, Huang C-L, Rothenfluh A, Rodan AR. (2022)  Chloride oscillations in pacemaker neurons regulate circadian rhythms through a chloride-sensing WNK kinase signaling cascade. Current Biology 32: 1429-38. LINK.

Merrill CB, Montgomery AB, Pabon MA, Rodan AR, Rothenfluh A. (2022)  Harnessing changes in open chromatin determined by ATAC-seq to generate insulin-responsive reporter constructs. BioRXiv LINK.  BMC Genomics 23: 399.  LINK.

Philyaw TJ, Rothenfluh A,Titos I. (2022) The Use of Drosophila to Understand Psychostimulant Responses. Biomedicines 10: 119. [review]  LINK

Titos I, Rothenfluh A.  (2021)  From single flies to many genes: Using Drosophila to explore the genetics of psychostimulant consumption. PNAS 118: e2109994118. [commentary]  LINK

*Mishra P, *Yang SEMontgomery AB, Reed AR, Rodan AR, Rothenfluh A. 
(2021)  The fly liquid-electroshock assay (FLEA) suggests opposite roles for neuropeptide F in avoidance of bitterness and shock. BMC Biology 19: 31.  LINK

Chvilicek MM, Titos IRothenfluh A.  (2020)  The Neurotransmitters Involved in Drosophila Alcohol-Induced Behavior. Frontiers in Behavioral Neuroscience 14: 607700. [review]  LINK.

Lathen DR, Merrill CBRothenfluh A.  (2020)  Flying Together: Drosophila as a Tool to Understand the Genetics of Human Alcoholism. International Journal of Molecular Science 21: E6649. [review]  LINK.

*Butts AR, *Ojelade SA, Pronovost ED, Seguin AMerrill CB, Rodan ARRothenfluh A.  (2019)  Altered actin filament dynamics in the Drosophila mushroom bodies lead to fast acquisition of alcohol consumption preference. Journal of Neuroscience 39: 8877-84. LINK.

Ojelade SA, Butts AR, Merrill CD, Privman Champaloux E, Aso Y, Wolin D, Cofresi RU, Gonzales RA, Rubin GM, Venton BJ, Rodan ARRothenfluh A.  (2019)  Dopaminergic learning and arousal circuits mediate opposing effects on alcohol consumption in DrosophilaBioRxiv  LINK.  [under review at eLife]

*Evangelou E, *Gao H, *Chu C, *Ntritsos G, Blakeley P, Butts AR, Pazoki R, Suzuki, Koskeridis, Yiorkas, Karaman, Elliott, Aeschbacher, Bartz, Baumeister, Braund,  Brown, Brody, Clarke, Dimou, Faul, Homuth, Jackson, Kentistou, Joshi, Lemaitre, Lind, Lyytikainen, Mangino, Milaneschi, Nelson, Nolte, Perala, Polasek, Porteous, Ratliff, Smith, Stancakova, Teumer, Tuominen, Theriault, Vangipurapu, Whitfield, Wood, Yao, Yu, Zhao, Arking, Auvinen, Liu, Mannikko, Risch, Rotter, Snieder, Veijola, Blakemore, Boehnke, Campbell, Conen, Eriksson, Grabe, Guo, van der Harst, Hartman, Hayward, Heath, Jarvelin, Kahonen, Kardia, Kuhne, Kuusisto, Laakso, Lahti, Lehtimaki, McIntosh, Mohlke, Morrison, Martin, Oldehinkel, Penninx, Psaty, Raitakari, Rudan, Samani, Scott, Spector, Verweij, Weir, Wilson, Levy, Tzoulaki, *Bell JD, *Matthews P, *Rothenfluh A, *Desrivieres S, *Schumann G, *Elliott P.  (2019)  New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.  Nature Human Behaviour. LINK

Blau J, Kloss B, Rothenfluh A.  (2018)  A speedy version of the double-time story.  Journal of the Japanese Society for Chronobiology  24: 45-49. [commentary]

Shalaby NA, Pinzon JH, Narayanan AS, Jin EJ, Ritz MP, Dove RJ, Wolfenberg H, Rodan AR, Buszczak, Rothenfluh A.  (2018)  JmjC domain proteins modulate circadian behaviors and sleep in Drosophila.  Scientific Reports  8: 815.  LINK

Gonzalez DA, Jia T, Pinzón JH, Acevedo SF, Ojelade SA, Xu B, Tay N, Desrivières S, Hernandez JL, Banaschewski T, Büchel C, Bokde ALW, Conrod PJ, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Martinot JL, Paus T, Smolka MN; IMAGEN Consortium, Rodan AR, Schumann G, Rothenfluh A.  (2018)  The Arf6 Activator Efa6/PSD3 Confers Regional Specificity and Modulates Ethanol Consumption in Drosophila and Humans.  Molecular Psychiatry  23: 621-628. LINK

Pinzón JH, Reed AR, Shalaby NA, Buszczak M, Rodan AR, Rothenfluh A. (2017)  Alcohol‐Induced Behaviors Require a Subset of Drosophila JmjC‐Domain Histone Demethylases in the Nervous System.  Alcohol Clin Exp Res  41: 2015-2024.  LINK

Shalaby NA, Sayed R, Zhang Q, Scoggin S, Eliazer S, Rothenfluh A, Buszczak M.  (2017)  Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila.  Scientific Reports  7: 5240.  LINK

Kaun KR, Rothenfluh A.  (2017)  Dopaminergic rules of engagement for memory in Drosophila.  Current Opinion in Neurobiology  43: 56–62.  [review]  LINK

Jia T, Macare C, Desrivières S, Gonzalez DA, Tao C, Ji X, Ruggeri B, Nees F, Banaschewski T, Barker GJ, Bokde AL, Bromberg U, Büchel C, Conrod PJ, Dove R, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Lemaitre H, Martinot JL, Paus T, Pausova Z, Poline JB, Rietschel M, Robbins T, Smolka MN, Müller CP, Feng J, Rothenfluh A, Flor H, Schumann G; IMAGEN Consortium.  (2016)  Neural basis of reward anticipation and its genetic determinants.  Proc Natl Acad Sci USA  113: 3879-3884.

Narayanan AS, Rothenfluh A.  (2016)  I believe I can fly! – Use of Drosophila as a Model Organism in Neuropsychopharmacology Research.  Neuropsychopharmacology  41: 1439-1446.  [review]

Ojelade SA, Acevedo SF, Kalahasti G, Rodan AR, Rothenfluh A.  (2015)  RhoGAP18B isoforms act on distinct Rho-family GTPases and regulate behavioral responses to alcohol via cofilin.  PLoS One  10: e0137465.

Acevedo SF, Peru y Colón de Portugal RL, Gonzalez DA, Rodan AR, Rothenfluh A.  (2015)  S6 kinase reflects and regulates ethanol-induced edation.  Journal of Neuroscience  35: 15396-15402.

Ojelade SA, Jia T, Rodan AR, Chenyang T, Kadrmas JL, Cattrell A, Ruggeri B, Charoen P, Lemaitre H, Banaschewski T, Büchel C, Bokde ALW, Carvalho FM, Conrod PJ, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Lubbe S, Martinot J-L, Paus T, Smolka MN, Spanagel R, O’Reilly PF, Laitinen J, Vejiola JM, Feng J, Desrivieres S, Jarvelin MR, the IMAGEN consortium, Schumann G, Rothenfluh A.  (2015)  Rsu1 regulates ethanol consumption in Drosophila and humans.  Proc Natl Acad Sci USA  112: E4085-4093.

Rothenfluh A, Troutwine BR, Ghezzi, A, Atkinson NS.  (2014)  Alcohol-Induced Behaviors in Invertebrate Model Organisms, Chapter 23 in:  Neurobiology of Alcohol Dependence.  Noronha ABC et al. ed. (Elsevier, Oxford UK) pp. 467-495.

Peru y Colón de Portugal RL, Ojelade SA, Penninti PS, Dove RJ, Nye MJ, Acevedo SF, Lopez T, Rodan AR, Rothenfluh A.  (2014)  Long-lasting, experience-dependent ethanol preference in Drosophila.  Addiction Biology  19: 392-401.

Ojelade SA, Rothenfluh A.  (2013)  Alcohol and Drosophila melanogaster. Chapter 6 in: Biological Research on Addiction: Comprehensive Addictive Behaviors and Disorders.  Miller PM ed. (Academic Press, San Diego) pp. 51–59.

Rothenfluh A, Cowan CW.  (2013)  Emerging roles of actin cytoskeleton regulating enzymes in drug addiction: actin or reactin’?  Current Opinion in Neurobiology  23: 507-12.  [review]

Chang L, Davison H, Kreko T, Cusmano T, Wu Y, Rothenfluh A, Eaton BA.  (2013)  Normal dynactin complex function during synapse growth in Drosophila requires membrane binding by Arfaptin.  Molecular Biology of the Cell  24: 1749-1764.

Peru y Colón de Portugal RL, Acevedo SF, Rodan AR, Chang LY, Eaton BE, Rothenfluh A  (2012)  Adult Neuronal Arf6 Controls Ethanol-Induced Behavior with Arfaptin Downstream of Rac1 and RhoGAP18B.  Journal of Neuroscience  32: 17706-17713.

Chen P, Tu X, Akdemir F, Chew SK, Rothenfluh A, Abrams JM.  (2012)  Genome-wide Silencing Identifies Effectors of Ethanol Induced Cell Death.  Cell Death & Differentiation  19: 1655-1663

Chan CC, Scoggin S, Wang D, Cherry S, Dembo T, Greenberg B, Jin J, Kuey C, Lopez A, Mehta S, Perkins TJ, Brankatsch M, Rothenfluh A, Buszczak M, Hiesinger PR.  (2011)  Functional Profiling of Rab GTPases in the Drosophila Brain.  Current Biology  21: 1704-1715.

Maples T, Rothenfluh A.  (2011)  A Simple Way to Measure Ethanol Sensitivity in Flies.  Journal of Visual Experimentation, doi: 10.3791/2541

Rodan AR, Rothenfluh A.  (2010)  The genetics of Drosophila alcohol responses.  International Review of Neurobiology  91: 25-51.  [review]

Ojelade SA, Rothenfluh A.  (2009)  Addiction: flies hit the skids.  Current Biology 190: R1110-1111.  [commentary]

Rothenfluh Publications From Before

Rothenfluh A, Threlkeld RJ, Bainton RJ, Tsai LT, Lasek AL, Heberlein U.  (2006)  Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B transcripts.  Cell  127: 199-211.

Rothenfluh A, Heberlein U.  (2006)  In vivo nicotine dose selection in Drosophila.  in: Guidelines on Nicotine Dose Selection for In Vivo Research. Matta SG ed.  Psychopharmacology  190: 297-302.

Heberlein U, Wolf FW, Rothenfluh A, Guarnieri DJ.  (2004)  Molecular genetic analysis of ethanol intoxication in Drosophila melanogaster.  Integr Comp Biol  44: 269-274.

Rothenfluh A, Heberlein U.  (2002)  Drugs, flies, and videotape: the effects of ethanol and cocaine on Drosophila locomotion.  Current Opinion in Neurobiology  12: 639-645.

*Kloss B, *Rothenfluh A, Young MW, Saez L.  (2001)  Phosphorylation of Period is influenced by physical associations of Double-time, Period, and Timeless in the Drosophila clock.  Neuron  30: 699-706.

Rothenfluh A, Young MW, Saez L.  (2000)  A TIMELESS-independent function for PERIOD proteins in the Drosophila clock.  Neuron  26: 505-14.

Rothenfluh A, Abodeely M, Young MW.  (2000)  Short-period mutations of peraffect a double-time-dependent step in the Drosophilaclock.  Current Biology  10: 1399-1402.

Rothenfluh A, Abodeely M, Price JL, Young MW.  (2000)  Isolation and analysis of six timeless alleles which cause short- or long-period circadian rhythms in Drosophila.  Genetics  156: 665-75.

Blau J and Rothenfluh A.  (1999)  Siesta-time is in the genes.  Neuron  24: 4-5.

*Price JL, *Blau J, Rothenfluh A, Abodeely M, Kloss B, Young MW. (1998)  double-time is a new Drosophila clock gene that regulates PERIOD protein accumulation.  Cell  94: 83-95. [One of 7 Key Publication for the 2017 Nobel Prize in Physiology or Medicine]

Kloss B, Price JL, Saez L, Blau J, Rothenfluh A, Wesley C, Young MW. (1998)  The Drosophila clock gene double-time encodes a protein closely related to human Casein kinase Ie.  Cell  94: 97-107.

Myers MP, Rothenfluh A, Chang M, Young MW.  (1997)  Comparison of chromosomal DNA composing timeless in Drosophila melanogaster and D.virilis suggests a new conserved structure for the TIMELESS protein.  Nucl Acids Res  25: 4710-14.

Myers MP, Wager-Smith K, Rothenfluh-Hilfiker A, Young MW.  (1996)  Light-induced degradation of TIMELESS and entrainment of the Drosophila circadian clock.  Science  271: 1736-40.

Sehgal A, Rothenfluh-Hilfiker A, Hunter-Ensor M, Chen Y, Myers MP, Young MW.  (1995)  Rhythmic expression of timeless: A basis for promoting circadian cycles in period gene autoregulation.  Science  270: 808-10.

Caroni P, Rothenfluh A, McGlynn E, Schneider C.  (1991)  S-cyclophilin. New member of the cyclophilin family associated with the secretory pathway.  J Biol Chem  266: 10739-42.